Simparica Trio for Dogs

If you are a dog breeder, you know the importance of tick prevention. Ticks are blood-sucking parasites that attach to mammals, including dogs, and feed on their blood. They reproduce quickly and can transmit serious diseases that weaken a dog's immune system, leaving them vulnerable to further illness.

One effective way to protect your dogs from ticks is with a preventive medication like Simparica Trio for Dogs. This medication helps prevent tick infestations and kills existing ticks before they can transmit diseases. It's essential to consult your veterinarian to determine the best tick prevention strategy for your dogs.

Simparica Trio for Dogs: Flea and Tick Defense

Simparica Trio, Complete Flea, Tick, and Heartworm Prevention for Dogs Chewable in One Tablet. It provides you with the following advantages:

  • To protect dogs from fleas.

  • Prevent ticks for dogs.

  • Heartworm prevention for dogs.

  • Preventing intestinal worms in dogs.

Simbarica Trio Triple contains three ingredients: sarolaner, Moxidectin, and Pyrantel. Sarolaner and moxidectin effectively kill and prevent fleas, ticks, and heartworms, while pyrantel helps control and prevent roundworms and hookworms.

The medication comes in chewable tablets that are easy for dogs to take. They are available in different sizes depending on the dog's weight. Overall, the Simbarica Trio is a convenient and effective way to protect your furry friend from parasites and keep him healthy and happy.

Each purchase comes with six treats to accompany dogs ages eight weeks and older, weighing between 44.1 and 88 lbs. Simbarica Trio is the first and only product that combines Sarulanero Moxidectin and Pyrantel in a treatment to help prevent heartworm infestations, killing fleas before they can lay eggs; it kills five types of ticks, treats and preventing flea infestation, and treats and combats worms, roundworms and hookworms.

Read more: Understanding Simparica: What Is It?

The Power of Simparica trio chewable tablets for dogs

Simparica Trio for Dogs

Simbarica Trio is the most effective product for getting rid of insects that infect dogs. These powerful, fast-acting oral tablets are specially designed to eliminate harmful parasites.

Providing your pet with effective relief within hours of ingestion. It is worth noting that the effectiveness of this product appears within a few hours of use and helps dogs get rid of insects. It also includes the following properties:


Simparica begins killing fleas within 3 hours and ticks within 8 hours of ingestion, ensuring quick relief for your pet.


Each delicious liver-flavored tablet provides a whole month of protection against fleas and ticks, keeping your pet safe year-round.


The chewable tablet can be given directly to your dog or mixed with food for a hassle-free experience.


Available in six weight categories, Simparica is suitable for dogs of all sizes, from minor to giant breeds.


Simparica is recommended for dogs over six months of age and weighing 2.8+ pounds. It has not been evaluated for use in kennels or pregnant or lactating dogs.

Read more: Do Dogs Get Menopause?

How Does Simparica Trio work?

Simbarica Trio for dogs is a medium-sized chewable tablet for dogs that kills adult fleas, helps prevent flea infestations, and treats and controls tick infestations. It protects your dog approximately three times longer than any other monthly treatment.

Our pick for the best oral flea control product for dogs is Simbarica Trio, a fast-acting chewable tablet that kills more parasites than any other oral product. The effectiveness of the product begins to appear within a few hours of being bitten and contributes to permanently getting rid of insects.

According to pet doctors' recommendations, products that are taken orally, such as tablets, are the most effective compared to those that are placed on the body. The medication is transferred to adult fleas when they bite your pet.

Some oral preventatives, such as Simbarica Trio, work by being absorbed into the bloodstream after ingestion and causing uncontrollable activity in the central nervous system of fleas and ticks, causing death.

Dosage and Application: Ensuring Your Pet's Safety

Simbarica Trio for dogs doses are divided according to the weight of the dog, according to the following table:

  • Purple: Dogs weighing between 2.6 and 5 kg (5.5-11 lbs).
  • Turquoise: For medium-sized dogs weighing 10.1-20 kg (22-44 lbs).
  • Brown: For large dogs weighing 40.1-60 kg (88-132 lbs).

Does Simparica Trio Expire?

Yes, Simparica Trio does expire.

Simparica Trio Expiration

Please consult your veterinarian before starting any new treatment for your pet. Always keep Simbarica Trio out of the reach of children. Please note that the package of 12 chews is intended for multiple use. Be sure to use all chewables before the expiration date for maximum effectiveness.

Simparica Trio Side Effects How Long Does it Last?

Simparica trio for dogs side effects: may cause neurological signs such as tremors, instability, and seizures in dogs with or without a history of neurological disorders. 

Simparica side effects observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, loss of appetite, otitis externa (ear infection), pruritus (itching), polyuria (urinating frequently), hyperactivity, and polydipsia (drinking more water).

Simparica Trio is influential for 35 days (5 weeks) after administration. This means it continues to kill fleas, ticks, and mites for that entire period. Maintaining a monthly dosing schedule ensures your dog's continuous protection.

Simparica Trio Side Effects Skin Irritation

Simparica Trio side effects itching and skin irritation are possible side effects of Simparica Trio, but they are uncommon. Here's what to watch for:

  • Symptoms: Itching, redness, or hair loss around the application area.
  • Severity: Skin irritation usually occurs less frequently than side effects like vomiting or diarrhea.
  • Cause: Your dog may have a sensitivity to an ingredient.

What to Do:

  • Monitor: Keep an eye on your dog after using Simparica Trio.
  • Mild Cases: No action is needed for minor, short-lived itching or redness.
  • Seek Veterinary Advice: If the irritation is severe, persists, or spreads, consult your veterinarian. They can recommend treatment and determine if Simparica Trio is your dog's best choice.

Is Simparica Trio Killing Dogs

No, Simparica Trio is not known for killing dogs. It's a parasite-preventative medication approved by the FDA for dogs. However, like any medication, there can be side effects.

Here's a breakdown:

  • Safe for Most Dogs: When used as directed by a veterinarian, Simparica Trio is generally safe and effective for most dogs.
  • Possible Side Effects: Some uncommon side effects include vomiting, diarrhea, lethargy, loss of appetite, and skin irritation. In rare cases, neurological signs like tremors or seizures have been reported.
  • Importance of Consulting a Vet: It's crucial to consult your veterinarian before using Simparica Trio, especially if your dog has any underlying health conditions or a history of neurological disorders.

simparica trio side effects puppy

Choosing Simparica Trio for Dogs: Why It's the Top Choice

Simparica Trio for Dogs

If you are still asking, is Simparica trio safe for dogs? 
Simparica Trio for dogs is considered one of the best tablets to treat dogs from lice and ticks. The effectiveness of this product is due to the following reasons:

  • Intestinal worm treatment: Effectively treats and controls hookworms and roundworms, including larval stages.
  • Continuous effectiveness: Ensures protection against fleas and ticks for up to 5 weeks (35 days).
  • Flea Life Cycle Disruption: Kills fleas before they lay eggs, preventing infestations in your home.
  • Allergy management: Provides relief from symptoms of flea allergy dermatitis.
  • Safe and versatile: Suitable for dogs under 8 weeks old and lightweight up to 2.8 lbs. It can be used along with other medications and is safe for dogs with heartworms.

Also check: Best tartar remover for dogs To keep your dog healthy


Simparica Trio is one of the best products for dogs. It effectively and safely gets rid of lice and ticks. The product may include some side effects, which can be overcome if the doses are applied according to the doctor’s instructions.